Project Summary

Reproduction and fertility is the only reason that life on this earth does not cease to exist and humans are no exception. Analysis of human spermatozoa is mostly carried out manually in the fertility labs and pathology labs. Technicians have to manually judge fast swimming sperms while looking at hundreds of them through a microscope, and label each based on the number of microns they move per second. They count them on mechanical counters.

Due to this reason, there is a large inter and intra lab variability, and the repeatability and accuracy of a certain semen sample varies quite poorly. Above this all, no record of the sample test is kept. Spermatozoa is a complicated mix, and tends to wither and die quickly once out in the open, so the time a sample is analyzed is also very crucial.

This procedure is about 20-25 minutes long. Due to all the inconsistencies in test approaches, same sample is diagnosed differently in different clinics and hence different clinics follow different treatments for the same quality of sperm sample.

We propose a system that will fix all the above problems; it will perform repeatable and accurate analysis of human spermatozoa by automatically finding each sperm and then tracking individual sperm to calculate its displacement accurate to the nearest micrometers using high speed cameras mounted on microscopes. Hence eliminating human errors and reducing test time to a mere minute or two. Sperm sample degrades with time, this system will store the state of the observed sample by capturing the original and processed videos and storing them for later review, hence preserving the state of the sample when it was analyzed.

There are over 250 fertility clinics only in UK, not to mention pathology labs. The PI along with Dr. Tomlinson Matthews (Head of Andrology Department, Queens Medical Center, Nottingham, UK) are already collaborating and Dr. Matthews has sent medical test equipment to pakistan for testing and development worth around 8000 GBP already. The intention is to develop an automated computer aided sperm analysis system and to validate it properly in clinical trials and publishing them at the end which will establish the credibility and performance of the system. These methods will be tested and used in the clinics at University of Nottingham Hospital, University of Liverpool and University of Cambridge, clinical trials will be done on these three sites. We believe that this tool has immense potential and will capture the European and American markets besides UK and Asia.
This tool apart from generating a lot of revenue, will work as a root for further research and collaboration between the PI and researchers in UK. And we intend to build additional analysis and diagnostic modules on top of the original proposed system in the future.

Core Team

  • Dr. Asad Naeem - Principal Investigator
  • Imran Ihsan - Project Manager
  • Faisal Fayyaz - Team Lead [Application Development]
  • Dr. Umair Rafique - Team Lead [Image Processing]

Technical Progress Report

A comprehensive architectural overview of the Computer Aided Sperm Analysis (CASA) System has been developed and a number of different architectural views are used to depict different aspects of the system.

Use Cases Diagnrams have been developed to mark major functionalities in Computer Aided Sperm Analysis (CASA) application. All the diagrams and descriptions are used standard methods of representing design architectures. Use-Case view is designed using UML 2.0 standards.

Project Deliverables

A Commerical Product of Computer Aided Sperm Analayis - CASA to find the Concentration and Motility of Sperms in a given sample.

Project News

First Quarter Milestones Completed and Presented to ICT.

Research Awards

  • ICTRNF Research Grant

    We recently won a research grant of 17.5 Million from ICT Fund to create a commercial medical application for Andrology Clinics. Work has started and the application prototype is already used in clinics in University of Cambridge, Oxford, Liverpool, Leeds and Nottingham (UK)

  • HEC Research Grant

    We are awarded 6 million rupees to study Morphology and abnormalities in Andrology samples for Humans. This grant will commence from September 2013 and will result in a medical tool as well.

  • 2nd & 3rd Place in ICTCOMPPEC 2011

    We Won two consecutive positions for our published research projects in this national and prestigious event.